By Yusuke Ohta
A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by means of catalytic domino response together with multi-component coupling was once constructed, and is the 1st instance of a three-component indole formation with out generating salts as a byproduct. in response to this response, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was once comprehensive which represents an extraordinary isoquinoline synthesis via a four-component coupling response. Following those effects, wide software experiences utilizing one-pot palladium-, acid-, or base-promoted cyclization printed that indole- or isoquinoline-fused polycyclic compounds could be with ease synthesized via multi-component reactions. because the proposal of eco-friendly Chemistry turns into ever extra vital, those findings may supply effective and atom-economical ways to the diversity-oriented synthesis of bioactive compounds containing a fancy constitution. this is able to bring about improvement of promising drug leads with structural complexity. The paintings of this thesis will pass directly to motivate the substitute learn of many readers.
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